п»їProduct info: Diabetes
Avandamet (METFORMIN + ROSIGLITAZONE) tablets contain 2 oral antihyperglycemic drugs used in the management of type 2 diabetes: Rosiglitazone maleate and metformin hydrochloride.
Rosiglitazone maleate is an oral antidiabetic agent, which acts primarily by increasing insulin sensitivity. Rosiglitazone improves glycemic control while reducing circulating insulin levels. Pharmacologic studies in animal models indicate that rosiglitazone improves sensitivity to insulin in muscle and adipose tissue and inhibits hepatic gluconeogenesis. Rosiglitazone maleate is not chemically or functionally related to the sulfonylureas, the biguanides, or the О±-glucosidase inhibitors.
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п»їMetformin and Rosiglitazone tablet
What is this medicine?
METFORMIN; ROSIGLITAZONE is a combination medicine used to treat type 2 diabetes. It helps to control blood sugar. Treatment is combined with diet and exercise.
What should I tell my health care provider before I take this medicine?
They need to know if you have any of these conditions:
anemia
become easily dehydrated
frequently drink alcohol-containing beverages
heart disease, failure
history of diabetic ketoacidosis
kidney disease
liver disease
polycystic ovary syndrome
serious infection or injury
swelling of the arms, legs, or feet; water retention
undergoing surgery or certain x-ray procedures with injectable contrast agents
vomiting
an unusual or allergic reaction to metformin; rosiglitazone, other medicines, foods, dyes, or preservatives
pregnant or trying to get pregnant
breast-feeding
How should I use this medicine?
Take this medicine by mouth with a glass of water. Take this medicine with meals. Take your medicine at the same time each day. Do not take more often than directed.
Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.
Patients over 65 years old may have a stronger reaction and need a smaller dose.
Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.
NOTE: This medicine is only for you. Do not share this medicine with others.
What if I miss a dose?
If it is almost time for your next dose, take only that dose. Do not take double or extra doses.
What may interact with this medicine?
Do not take this medicine with any of the following medications:
dofetilide
gatifloxacin
certain contrast medicines given before X-rays, CT scans, MRI, or other procedures
This medicine may also interact with the following medications:
amiloride
digoxin
diuretics
female hormones, like estrogens or progestins and birth control pills
gemfibrozil
isoniazid
medicines for blood pressure, heart disease, irregular heart beat
morphine
nicotinic acid
phenothiazines like chlorpromazine, mesoridazine, prochlorperazine, thioridazine
phenytoin
procainamide
quinidine
quinine
ranitidine
rifampin
steroid medicines like prednisone or cortisone
stimulant medicines for attention disorders, weight loss, or to stay awake
thyroid medicines
trimethoprim
vancomycin
This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.
What should I watch for while using this medicine?
Visit your doctor or health care professional for regular checks on your progress.
Your health care professional will have to check blood tests regularly to assess the effect of this medication on your liver.
Learn how to check your blood sugar. Learn the symptoms of low and high blood sugar and how to manage them.
If you have low blood sugar, eat or drink something that has sugar. Make sure others know to get medical help quickly if you have serious symptoms of low blood sugar, like if you become unconscious or have a seizure.
If you need surgery or if you will need a procedure with contrast drugs, tell your doctor or health care professional that you are taking this medicine.
Wear a medical identification bracelet or chain to say you have diabetes, and carry a card that lists all your medications.
What side effects may I notice from this medicine?
Side effects that you should report to your doctor or health care professional as soon as possible:
allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
breathing problems
dark urine
dizziness
fever, chills, sore throat
low blood sugar (ask your doctor or healthcare professional for a list of these symptoms)
muscle aches or pains
nausea, vomiting, unusual stomach upset or pain
pain in bone, joint
redness, blistering, peeling or loosening of the skin, including inside the mouth
sudden weight gain
swelling of the hands, legs, and/or feet
unusually weak or tired
yellowing of the eyes or skin
Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):
backache
headache
high blood sugar
injury
fatigue
This list may not describe all possible side effects.
Where should I keep my medicine?
Keep out of the reach of children.
Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Protect from moisture and light. Throw away any unused medicine after the expiration date.
What is the shelf life of the pills?
The expiry date is mentioned on each blister. It is different for different batches. The shelf life is 2 years from the date of manufacture and would differ from batch to batch depending on when they were manufactured.
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