п»їProduct info: Diabetes
Avandamet (METFORMIN + ROSIGLITAZONE) tablets contain 2 oral antihyperglycemic drugs used in the management of type 2 diabetes: Rosiglitazone maleate and metformin hydrochloride.
Rosiglitazone maleate is an oral antidiabetic agent, which acts primarily by increasing insulin sensitivity. Rosiglitazone improves glycemic control while reducing circulating insulin levels. Pharmacologic studies in animal models indicate that rosiglitazone improves sensitivity to insulin in muscle and adipose tissue and inhibits hepatic gluconeogenesis. Rosiglitazone maleate is not chemically or functionally related to the sulfonylureas, the biguanides, or the О±-glucosidase inhibitors.
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п»їAvandamet
Generic Name: Rosiglitazone/Metformin Tablets (ROE-zi-GLI-ta-zone/met-FOR-min)
Brand Name: Avandamet
Avandamet may rarely cause a serious and sometimes fatal condition called lactic acidosis. Most of these cases have occurred in diabetic patients who also have certain kidney problems. The risk of lactic acidosis may be greater if you have liver problems, kidney problems, or heart failure. The risk may also be greater in patients who are elderly or who drink alcohol. Lab tests, including kidney function, may be performed while you take Avandamet .
Do not begin to take Avandamet if you are more than 80 years old unless lab tests show that you do not have decreased kidney function. Do not take it if you have a severe infection or low blood oxygen levels, or are dehydrated. Tell your doctor you take Avandamet before you have any surgery or lab procedures.
Contact your doctor right away if you notice symptoms such as muscle pain or tenderness; unusual drowsiness, dizziness, or lightheadedness; slow or irregular heartbeat; fast or difficult breathing; unusual stomach discomfort; or unusual weakness or tiredness. Contact your doctor right away if you start to feel unusually cold, or if you have a general feeling of being unwell.
Thiazolidinedione antidiabetics such as Avandamet may cause or worsen heart failure in some patients. They may also increase the risk of certain other severe heart problems (eg, chest pain, heart attack). Tell your doctor if you have a history of heart failure. Avandamet should not be used to treat patients with moderate to severe heart failure. You will be monitored for signs of heart failure when you start Avandamet and when your dose increases. Contact your doctor at once if you develop swelling of the hands, ankles, or feet; shortness of breath; sudden unexplained weight gain; chest pain; numbness of an arm or leg; sudden severe headache, dizziness, or vomiting; sudden vision changes; or fainting. Your doctor may need to stop your medicine or change your dose.
Avandamet is used for:
User Reviews & RatingsAs a treatment for... Avg User Ratings [?]
Diabetes, Type 2
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Treating type 2 diabetes. It is used along with diet and exercise. It may be used alone or with other antidiabetic medicines.
Avandamet is a thiazolidinedione and biguanide antidiabetic combination. It works by decreasing the amount of sugar that the liver produces and the intestines absorb. It also helps to make your body more sensitive to the insulin that you naturally produce.
Do NOT use Avandamet if:
you are allergic to any ingredient in Avandamet
you have type 1 diabetes
you have moderate to severe heart failure
you have had a severe infection, low blood oxygen levels, kidney or liver problems, high blood ketone or acid levels (eg, diabetic ketoacidosis), or a type of diabetic eye problem (macular edema), or you are severely dehydrated
you have had a stroke or a recent heart attack, or you are in shock
you are 80 years old or more and have not had a kidney function test
you will be having surgery or certain lab procedures
you have a history of liver problems, including jaundice (yellowing of the skin or eyes), during therapy with a similar medicine called troglitazone
you are taking a nitrate (eg, nitroglycerin) or using insulin
Contact your doctor or health care provider right away if any of these apply to you.
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