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Avapro (Irbesartan) is used for treating high blood pressure. It may be used alone or with other blood pressure medicines. It is also used for treating kidney disease in patients with type 2 diabetes.

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п»їIRBESARTAN (Systemic)


Some commonly used brand names are:

In the U.S.—
Avapro
Category
Antihypertensive
Description

Irbesartan (ir-be-SAR-tan) belongs to the class of medicines called angiotensin II inhibitor antihypertensives. It is used to treat high blood pressure (hypertension).

High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. High blood pressure also may increase the risk of heart attacks. These problems may be less likely to occur if blood pressure is controlled.

Irbesartan works by blocking the action of a substance in the body that causes blood vessels to tighten. As a result, irbesartan relaxes blood vessels. This lowers blood pressure.

This medicine is available only with your doctor's prescription, in the following dosage form(s):
Oral
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Before Using This Medicine

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For irbesartan, the following should be considered:

Allergies—Tell your doctor if you have ever had any unusual or allergic reaction to irbesartan. Also tell your health care professional if you are allergic to any other substances, such as foods, preservatives, or dyes.

Pregnancy—Use of irbesartan during pregnancy, especially during the second and third trimesters (after the first 3 months), can cause low blood pressure, severe kidney failure, or even death in the newborn. Therefore, it is important that you check with your doctor immediately if you think that you may have become pregnant . Be sure that you have discussed this with your doctor before taking this medicine.

Breast-feeding—It is not known whether irbesartan passes into breast milk. However, irbesartan passes into the milk of lactating rats. Because this medicine may cause serious side effects, breast-feeding is generally not recommended while you are taking it.

Children—This medicine has been tested in children over 6 years of age and has not been shown to cause different side effects or problems than it does in adults.

Older adults—This medicine has been tested in patients 65 years of age or older and has not been shown to cause different side effects or problems in older people than it does in younger adults. However, blood levels of irbesartan may be increased in the elderly and elderly patients may be more sensitive to the effects of irbesartan.

Other medicines—Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking irbesartan, it is especially important that your health care professional know if you are taking any of the following:
Diuretics (water pills)—Effects on blood pressure may be increased

Other medical problems—The presence of other medical problems may affect the use of irbesartan. Make sure you tell your doctor if you have any other medical problems, especially:
Congestive heart failure, severe—Lowering of blood pressure by irbesartan may make this condition worse
Dehydration—Blood pressure-lowering effects of irbesartan may be increased.
Kidney disease—Effects of irbesartan may be increased because of slower removal of medicine from the body.


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Isotretinoin, a retinoid, is available as Accutane in 10-mg, 20-mg and 40-mg soft gelatin capsules for oral administration. Each capsule contains beeswax, butylated hydroxyanisole, edetate disodium, hydrogenated soybean oil flakes, hydrogenated vegetable oil, and soybean oil. Gelatin capsules contain glycerin and parabens (methyl and propyl), with the following dye systems: 10 mg — iron oxide (red) and titanium dioxide; 20 mg — FD&C Red No. 3, FD&C Blue No. 1, and titanium dioxide; 40 mg — FD&C Yellow No. 6, D&C Yellow No. 10, and titanium dioxide.

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Isotretinoin is a retinoid, which when administered in pharmacologic dosages of 0.5 to 1.0 mg/kg/day (see DOSAGE AND ADMINISTRATION), inhibits sebaceous gland function and keratinization. The exact mechanism of action of isotretinoin is unknown.
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if you have a history of giant hives or skin inflammation, or hardening of the skin or organs
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if you are undergoing dialysis
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